Journal of
Medical Genetics and Genomics

  • Abbreviation: J. Med. Genet. Genomics
  • Language: English
  • ISSN: 2141-2278
  • DOI: 10.5897/JMGG
  • Start Year: 2009
  • Published Articles: 48

Full Length Research Paper

Role of pyruvate dehydrogenase kinases (PDK’s) and their respective microRNA’s in human ovarian cancer

Sheema Sameen1, Zoya Khalid1 and Shaukat Iqbal Malik2*
1Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, Pakistan. 2Department of Bioinformatics, Muhammad Ali Jinnah University (MAJU) New Campus, Islamabad, Pakistan.
Email: [email protected]

  •  Accepted: 13 October 2011
  •  Published: 31 October 2011


Cancer is a metabolic disorder and in energy metabolism, pyruvate dehydrogenase kinases (PDKs) play a very vital role, which make them important candidate for involvement in cancer. The bioinformatics analysis performed on ovarian cancer data sets taken from gene expression Omnibus proved the up regulation of PDK2 and PDK4. The regulating microRNA’s for these two genes were also predicted computationally, which were found down regulated in cancer and hence confirmed the over expression of PDK2 and PDK4. Further investigations on the behaviour of PDK’s and their corresponding microRNA’s will provide a major breakthrough in cancer research and investigation.


Key words: Pyruvate dehydrogenase kinase( PDK), metabolic disorder, ovarian cancer, microRNA.