Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3704

Full Length Research Paper

Effect of Vernonia amygdalina supplemented diet on selected tissues function in diet-induced obese rats

Item J. Atangwho*, Emmanuel E. Edet, Godwin E. Egbung, Daniel E. Uti and Patrick E. Ebong
Item J. Atangwho*, Emmanuel E. Edet, Godwin E. Egbung, Daniel E. Uti and Patrick E. Ebong
Email: [email protected], [email protected]

  •  Accepted: 20 May 2013
  •  Published: 03 July 2013

Abstract

The present study investigated the impact of Vernonia amygdalina (VA) supplemented diet on blood parameters, and liver and kidney functions in diet-induced obese rats. VA supplemented diet (5 and 15%) was fed for 4 weeks and compared to orlistat (5.14 mg/kg b.w., p.o.), an anti-obesity drug. Full blood counts and some biochemical indices were measured at the end of the study. Platelet count which decreased in obese rats (56.17%, P< 0.05), was increased by orlistat (40.70%), 5% (51.34%) and 15% (97.63%, < 0.05) VA diets, respectively. Also, 15% VA diet only, lowered leukocyte counts by 31.75% (P < 0.05), indicative of anti-inflammation. Obesity-induced hepatotoxicity indicated by elevated serum alanine amino transferase (32.58%, P < 0.05), aspartate amino transferase (19.69%) activities and lowered AST:ALT ratio (14.62%) were respectively ameliorated. However, both treatments failed to up regulate the hitherto decreased total protein level (29.84%, P < 0.05), but modulated the altered albumin levels. Depressed sodium level in obese rats (58.24%, P < 0.05), was upregulated (P < 0.05). Orlistat and 15% VA diet only, respectively increased chloride (P < 0.05) and calcium (38.15%, P < 0.05 and 22.00%). The depressed urea level (58.48%, P < 0.05) was partially resolved, but null effect on increased creatinine (< 0.05). VA diet may exert anti-inflammatory, hepatopretective and nephrotoprotective actions in obesity.

 

Key words: Vernonia amygdalina Del., diet-induced obesity, liver function, kidney function, haematological indices.