Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3778

Full Length Research Paper

Effects of the extract of Forsythia suspensa on influenza A H1N1 infection in vitro

Su Wen1, Xu Huifu1and Huang Hao2*
1Department of Paediatrics, Wuhan First Hospital, Wuhan 430022, P. R. China. 2Center of Experimental Medicine, Wuhan First Hospital, Wuhan 430022, P. R. China
Email: [email protected]

  •  Accepted: 22 July 2010
  •  Published: 30 September 2013

Abstract

The present study investigated the effect of the extract of Forsythia suspensa(FSE) on the infection of MDCK cells by anti-H1N1 virus. The protective effect of FSE on the infected MDCK cells was evaluated through quantitative measurement of the changes in the cytopathic effects and by the ultraviolet (UV) absorbance at 600 nm. It was found that FSE was toxic to MDCK cells at a higher concentration, while it had a marked inhibitory effect on cell pathological changes at a lower concentration. Our findings demonstrate that FSE has a significant protective effect on MDCK cells infected in a dose-dependent manner, suggesting that FSE can be developed as an anti-virus agent.

 

Key words: Forsythia suspense, H1N1 virus, the cytopathic effects.