Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3749

Full Length Research Paper

Traditional Chinese medicine Zizhu ointment alleviates inflammatory activity during wound healing in diabetic rats

Qiang Han
  • Qiang Han
  • Shuguang Hospital Affiliated to Shanghai Traditional Chinese Medical University, Shanghai 201203, China.
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Liang Qin
  • Liang Qin
  • Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
  • Google Scholar
Xiao Yang
  • Xiao Yang
  • Shuguang Hospital Affiliated to Shanghai Traditional Chinese Medical University, Shanghai 201203, China.
  • Google Scholar
Renyan Huang
  • Renyan Huang
  • Shuguang Hospital Affiliated to Shanghai Traditional Chinese Medical University, Shanghai 201203, China.
  • Google Scholar
Xiaoming Hu
  • Xiaoming Hu
  • Shuguang Hospital Affiliated to Shanghai Traditional Chinese Medical University, Shanghai 201203, China.
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Wenhui Li
  • Wenhui Li
  • Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
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Guobin Liu
  • Guobin Liu
  • Shuguang Hospital Affiliated to Shanghai Traditional Chinese Medical University, Shanghai 201203, China.
  • Google Scholar


  •  Received: 24 June 2020
  •  Accepted: 06 October 2020
  •  Published: 31 August 2021

Abstract

Diabetic ulcers are a severe complication in patients with diabetes that often lead to amputation. The etiology of diabetes-induced wound healing impairment is multi-faceted. Persistent inflammation and deficient tissue regeneration have been suggested to impair wound healing in diabetes patients. Although new therapeutic approaches have been developed, many chronic wound treatments remain unsatisfactory, and more promising therapeutics are urgently needed. We thus developed diabetic wounding models with or without bacterial infection in rats that are optimized for testing a traditional Chinese medicine-Zizhu ointment. We observed increased proinflammatory markers and decreased angiogenesis in both non-infected and infected diabetic wounded rats. These changes were normalized by Zizhu ointment. Additionally, activation of Phosphatidylinositol-3-kinase (PI3K), c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NF-κB) were observed in diabetic wounded rats, whereas Zizhu ointment significantly inhibited activation of these proteins. Our results suggest that Zizhu ointment promotes wound healing by inhibiting the inflammatory response.

Key words: Zizhu ointment, diabetic wounding, inflammation, angiogenesis, nuclear factor-kappa B (NF?κB).