In present study, the hepatoprotective activity of chloroform and ethanol extracts ofGmelina asiatica Linn. (Verbenaceae) aerial parts were evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats. The extracts at dose of 400 mg/kg were administered orally once daily. The substantially elevated serum enzyme levels of aspartate aminotransferase (AST), alanine transaminase (ALT), serum alkaline phosphatase (SALP) and total bilirubin were restored towards normalization significantly by the extracts. Silymarin was used as standard reference and exhibited significant hepatoprotective activity against carbon tetrachloride induced haptotoxicity in rats. The biochemical observations were supplemented with histopathological examination of rat liver sections. The results of this study strongly indicate that G. asiatica aerial parts have potent hepatoprotective action against carbon tetrachloride induced hepatic damage in rats. Ethanol extract was found more potent hepatoprotective. Meanwhile, in vivoantioxidant and free radical scavenging activities were also screened which were positive for both chloroform and ethanol extracts. This study suggests that possible mechanism of this activity may be due to free radical-scavenging and antioxidant activities which may be due to the presence of flavonoids in the extracts.
Key words: Gmelina asiatica Linn, carbon tetrachloride, anti-hepatitis activity, antioxidant activity, silymarin, histopathology.
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