Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3843

Full Length Research Paper

Antipsychotic effect of aqueous stem bark extract of Amblygonocarpus andongensis in Wistar albino rats

Abdullahi Aliyu Ebbo1, Abdullahi Teleh Elsa2, Emmanuel Udok Etuk3, Mohammed Jengebe Ladan4 and Saganuwan Alhaji Saganuwan5*
1Department of Veterinary Pharmacology, Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, P. M. B. 2346 Sokoto, Sokoto State, Nigeria. 2Department of Veterinary Medicine, Surgery and Theriogenology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, P. M. B. 2346 Sokoto, Sokoto State, Nigeria. 3Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University, P. M. B. 2346 Sokoto, Sokoto State, Nigeria. 4Department of Chemistry, Faculty of Sciences, Usmanu Danfodiyo University, P. M. B. 2346 Sokoto, Sokoto State, Nigeria. 5Department of Veterinary Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Agriculture, P. M. B. 2373, Makurdi, Benue State, Nigeria.
Email: [email protected]

  •  Accepted: 22 January 2010
  •  Published: 04 June 2010

Abstract

The study of antipsychotic effect of the aqueous stem bark extract ofAmblygonocarpus andongensis was carried out on amphetamine induced psychosis in 42 Wistar albino rats weighing between 105 and 305.2 g using feeding and locomotor activities as indices of psychosis. All the experimental rats were given psychotic symptoms through amphetamine use, they were treated with nothing (control), low, moderate and high doses of bark and chlorpromazine (active comparator) and then the psychotic symptoms were monitored to see which group exhibited the best response. The highest dose extract (1350 mg/kg) was comparable to chlorpromazine in lowering psychotic behavior characterized by annorexia and agitation. Hence both A. andongensisand chlorpromazine can be used to treat psychosis induced by amphetamine. The antipsychotic effect of andongensis may be in dose graded fashion.

 

Key words: Amblygonocarpus andongensis, antipsychotic effect, Wistar rat, agitation, anorexia.

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