Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3804

Full Length Research Paper

Study of antihyperlipidemic effect on rabbits of 8-alkylberberine derivatives

Xiaoli Ye1, Xin Chen2, Kai He1, Jun Yi2, Xuegang Li2*, Ping Li3 and Xiaohong Wang3
1School of Life Science, Southwest University, Chongqing 400715, China. 2Chemistry Institute of Pharmaceutical resources, School of Pharmaceutical Science, Southwest University, Chongqing 400716, China. 3Beibei Tranditional Chinese Medicie Hospital, Chongqing, 400700, China.
Email: [email protected]

  •  Accepted: 24 January 2011
  •  Published: 18 April 2011


To study the antihyperlipidemic effect of 8-alkyl-berberine derivatives (8-BBR-Cn). The experimental hyperlipidemia rabbits were prepared by feeding with high cholesterol and high fat (HCHF) diet. Then the effects of 8-alkyl-BBR on the serum levels of total cholesterol (TC), triglyceride (TG), (HDL-C), low density lipoprotein-cholesterol (LDL-C) and highdensity lipoprotein-cholesterol (HDL-C) in rabbit blood were measured and those on hepatic and kidney function were observed. 8-BBR-Cn effectively decreased the serum content of TC, TG, LDL-C and increased HDL-C level in hyperlipidemic rabbits, compared with berberine. The antihyperlipidemic effect was increased with elongating the alkyl chain of 8-BBR-Cn. Among all synthesized derivatives, 8-cetyl-berberine (8-BBR-C16) showed the highest antihyperlipidemic effect, which was a dose-effect relationship on blood lipid. Pathological examination indicated that 8-BBR-C16 could recover the liver tissue of rabbits damaged by high lipid diet. 8-BBR-C16 showed a strong antihyperlipidemia effect with low toxicity, thus it might be a promising drug of antihyperlipidemic.


Key words: Berberine (BBR), 8-alkyl-berberine derivatives (8-BBR-Cn), antihyperlipidemic effect.