Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3798

Full Length Research Paper

Antioxidant activities of Punica granatum (pomegranate) peel extract on brain of rats

Ahmed E. Abdel Moneim
Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.
Email: [email protected]

  •  Accepted: 09 May 2011
  •  Published: 31 January 2012


Methanol extract of Punica granatum (pomegranate) peel was screened for its antioxidant activity on brain of adult male Wister albino rats. The antioxidant activity was determined by measuring reduced glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidase. In addition, hydrogen peroxide (H2O2), nitric oxide (NO) and lipid peroxidation (MDA) were also measured in brain homogenate. Pomegranate peel treatment resulted in marked increase in most antioxidant parameters with reduction in oxidant H2O2, NO and MDA. On the basis of the previous results it can be concluded that pomegranate methanol peel extract is a promising natural product, which could be useful for the prevention of neurodegenerative diseases caused by oxidative stress.


Key words: Pomegranate peel, antioxidant enzymes, brain, rats.