Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3812

Full Length Research Paper

Toxicity studies on an unripe Carica papaya aqueous extract: biochemical and haematological effects in wistar albino rats

Oduola, T1*, Adeniyi F. A. A.2, Ogunyemi E. O.3, Bello, I. S.4, Idowu T. O5 and Subair, H.G6    
1Department of Haematology, Special Investigations Laboratory, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. 2Department of Chemical Pathology, University of Ibadan, Ibadan, Nigeria. 3Department of Chemical Pathology, Olabisi Onabanjo University, Ago-Iwoye, Nigeria. 4Department of General Medical Practice, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. 5Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife. Nigeria. 6Department of Pharmacology, Drug Research and Production unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.    
Email: [email protected]

  •  Accepted: 21 June 2007
  •  Published: 31 August 2007


Aqueous extract of unripe Carica papaya is consumed by some sickle cell patients for its antisickling activities in some parts of southern Nigeria without considering its safety. The effects of the extract on functions of the liver, kidney and bone marrow were investigated in 30 wistar albino rats. The rats were in 6 groups of 5 animals per group. The first group is the control and the other five groups were the study groups. The oral acute toxicity of the extract (LD50) was determined, different doses, 50, 100, 150, 200 and 250 mg/kg were administered daily to the study groups (A, B, C, D, E) respectively for 6 weeks. Liver, kidney and bone marrow function tests were assessed using standard techniques. The results obtained for biochemical and haematological parameters for the control and experimental groups showed no statistical significant different (P>0.05). This result showed that the intake of unripe C.  papaya extract had no adverse effects on the functions of these organs in rats.


Key wordsCarica papaya, aqueous extract, liver, kidney, bone marrow, antisickling.