Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3797

Full Length Research Paper

Nobiletin, a polymethoxylated flavone from citrus peels, induces differentiation of normal human epidermal keratinocytes

Kenji Ohguchi*,
  • Kenji Ohguchi*,
  • Department of Food and Nutrition, Sugiyama Jogakuen University, Aichi 464-8662, Japan.
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Munekazu Iinuma
  • Munekazu Iinuma
  • Laboratory of Pharmacognosy, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
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Yoshinori Nozawa
  • Yoshinori Nozawa
  • Department of Food and Health, Tokai Gakuin University, Gifu 504-8511, Japan.
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Masafumi Ito
  • Masafumi Ito
  • Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan.
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  •  Received: 24 January 2014
  •  Accepted: 25 August 2014
  •  Published: 03 September 2014

Abstract

Nobiletin, a polymethoxylated flavone from citrus peels, is known to have a wide range of pharmacological activities. In this study, we examined the effects of nobiletin on differentiation of normal human epidermal keratinocytes (NHEKs). Treatment of NHEKs with nobiletin was found to cause marked increases in the expression level of keratin 10 (K10) and involucrin, differentiation makers of keratinocytes.

 

Key words: Nobiletin, polymethoxylated flavone, citrus, keratinocyte, keratin.