Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3574

Full Length Research Paper

Andiroba oil (Carapa guianensis) on ventral hernia repair

Edson Yuzur Yasojima*
  • Edson Yuzur Yasojima*
  • Division of Gastroenterology Surgery, University of Sao Paulo, Brazil
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Felipe Lobato da Silva Costa
  • Felipe Lobato da Silva Costa
  • Para State University, Brazil.
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Abdallah de Paula Houat
  • Abdallah de Paula Houat
  • Para State University, Brazil.
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Renan Kleber Costa Teixeira
  • Renan Kleber Costa Teixeira
  • Para State University, Brazil.
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Edvaldo Lima Silveira
  • Edvaldo Lima Silveira
  • Infectious and Parasitic Diseases, University of Para, Brazil.
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Marcus Vinicius Henriques Brito
  • Marcus Vinicius Henriques Brito
  • Para State University, Brazil.
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Gaspar de Jesus Lopes Filho
  • Gaspar de Jesus Lopes Filho
  • Division of Gastroenterology Surgery, University of Sao Paulo, Brazil
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  •  Received: 19 November 2013
  •  Accepted: 28 April 2014
  •  Published: 17 May 2014

Abstract

In the Amazon rainforest region, Andiroba oil is an herbal oil that is widely used by the local population to treat several inflammatory diseases. The objective of this study was to test Andiroba oil as a mesh coating or by oral administration in a rat model of excisional abdominal wall defect as an alternative to modulate inflammatory response without impairing the ventral hernia repair. Thirty six animals were distributed into three groups (N=12). (1) In the control group (CONT), ventral hernia repair was done using polypropylene/polyglecaprone mesh. (2) In the Andiroba oil gavage group (AndG), animals were treated with the meshes and 0.63 ml/kg of Andiroba oil was given by oral administration for 7 days prior to the mesh placement. (3) In the Andiroba oil submersion group (AndS), animals were treated with meshes that were previously submersed in Andiroba oil. At the 7th, 14th, and 21st days, macroscopic and microscopic analyses were done. AndG had fewer adhesions, necrosis, and lymphocytes, as well as similar collagen fiber formation and fibrosis areas as CONT. AndS showed a higher number of macrophages, fibrosis area, and less collagen fiber formation. Oral administration of Andiroba oil modulated inflammatory response, reduced abdominal adhesion formation, and did not impair tissue healing.

Key words: Abdominal wall, wound healing, Andiroba, herbal, cicatrization.

Abbreviation

VHR, Ventral hernia repair; AndG, Andiroba oil gavage group; AndS, Andiroba oil submersion group; CONT, control group.