To determine the effects of grape seed extract (GSE) supplementation on antioxidant defense system and lipid peroxidation in persons with type 2 diabetes mellitus (T2D). During a randomized double blind clinical trial adult subjects with type 2 diabetes were supplemented with 200 mg/day of GSE or placebo for two months. Fasting blood samples were obtained at the beginning and the end of study to determine total antioxidant capacity (TAC), superoxide dismutase (SOD) and glutathione peroxidase (GPX) levels in red blood cells and the serum malondialdehyde levels (MDA). After 2 months of grape seed extract supplementation, TAC decreased significantly from 0.71±0.17 to 0.7±0.15 (p<0.05) and SOD increased significantly from 1453±210 to 1514±243 (p<0.05) with no significant changes in MDA and GPX concentrations. There were no significant differences in the levels of TAC, SOD, GPX and MDA between groups (P > 0.05) during study. Although there were significant changes in TAC and SOD levels in GSE group, but there were no significant differences compared to placebo group. Therefore that is better to more investigation performed with upper dose and longer time by attention to special condition of diabetes and the medicines that are consumed.
Key words: Grape seed extract, oxidative stress, antioxidant status, lipid peroxidation, diabetes.
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