Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3823

Full Length Research Paper

Potential activity of ethanolic extract of Boesenbergia rotunda (L.) rhizomes extract in accelerating wound healing in rats

A. A. Mahmood1*, Abdalbasit A. Mariod2, Siddig Ibrahim Abdelwahab2, Salmah Ismail1 and Fouad Al-Bayaty3
1Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. 2Department of Food Science and Technology, College of Agricultural Studies, Sudan University of Science and Technology, P. O. Box 71, Khartoum, North Sudan. 2Institute of Bioscience, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. 3Department of Oral Medicine and Periodontology, Faculty of Dentistry, University Technology Mara, 40000, Shah Alam, Selangor, Malaysia.
Email: [email protected]

  •  Accepted: 18 June 2010
  •  Published: 04 August 2010


This study was conducted to evaluate the effects of topical application of ethanol extract of Boesenbergia rotunda rhizomes on the rate of wound healing closure and histology of healed wound. An area of uniform wound 2.00 cm in diameter using circular stamp, was excised from the nape of the dorsal neck of all rats with the aid of round seal. The animal groups were topically treated with 0.2 ml of each vehicle (gum acacia), Intrasite gel, 100 and 200 mg/ml of ethanol extract, respectively. Macroscopically, wound dressed with rhizomes extract and Intrasite gel significantly healed earlier than those treated with vehicle. Histological analysis of healed wounds dressed with rhizomes extract showed comparatively less scar width at wound closure and healed wound contained less inflammatory cells and more collagen with angiogenesis compared to wounds dressed with vehicle. In conclusion, wounds dressed with rhizomes extract significantly enhanced the acceleration of wound healing enclosure in rats.


Key words: Boesenbergia rotunda, rhizomes, ethanol extract; wound healing, histology.