Urtica urens is classified into the sub family of Rosales, belonging to the Urticaceae family. Their well-established beneficial properties to human health were mainly related to their phenolic content. Nettle extracts showed that an antioxidant and antimicrobial potentials. Among the different nettle extracts methanol extract (EMO) has the highest phenolic content (86.5±1.36 mg EGA/g DM) and lowest value was observed in the water extract (EAO) (43.915 ± 19.95 mg EAG/g DM). The stronger inhibitory effect on 1,1-diphenyl-2-picryl-hydrazil radicals (DPPH•) corresponds to those obtained from methanol extract. A comparative analysis between two fungi Penicelleum notatum and Fusarium oxysporum, showed a decrease growth rate and was monitored at the range of 1 to 2.5 mg/ml. Complete growth inhibition of these two fungi was obtained at the concentrations of 5, 10, and 15 mg/ml of water extract (EAO). The antibacterial activity was also significant while addition of the nettle extracts and depends on the strain tested. Gram positive bacterial strains (Enterococcus faecalis and Enterecoccus faecium) showed higher sensitivity to the extracts, in comparison with Gram negative strains Escherichia coli and Salmonella typhimurium. The antioxidant activities were correlated (r2> 0.9) with the phenolic content, suggesting that the phenolic content are playing major role in scavenging free radicals. Our total findings suggest that the Nettle (Urtica urens) extract has important antioxidant and antimicrobial activities which is positively correlated with its phenolic content.
Key words: Urtica urens, polyphenol, antioxidant, antimicrobial and 1,1-diphenyl-2-picryl-hydrazil radicals (DPPH•).
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