Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3693

Full Length Research Paper

Antibacterial, antifungal and in vitro cytotoxic activities of three extracts isolated from mint

Dongbo Liu
  • Dongbo Liu
  • Horticulture and Landscape College, Hunan Agricultural University, Changsha, P. R. China.
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Liqin Hu
  • Liqin Hu
  • Horticulture and Landscape College, Hunan Agricultural University, Changsha, P. R. China.
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Xuehui Liu
  • Xuehui Liu
  • Horticulture and Landscape College, Hunan Agricultural University, Changsha, P. R. China.
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Xincong Kang
  • Xincong Kang
  • Horticulture and Landscape College, Hunan Agricultural University, Changsha, P. R. China.
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Yongquan Hu
  • Yongquan Hu
  • Horticulture and Landscape College, Hunan Agricultural University, Changsha, P. R. China.
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Hongqi Xie
  • Hongqi Xie
  • Horticulture and Landscape College, Hunan Agricultural University, Changsha, P. R. China.
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Zhilan Xia
  • Zhilan Xia
  • Hunan Engineering Research Center of Edible Fungi, Changsha, P. R. China.
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Ling Xie*
  • Ling Xie*
  • Horticulture and Landscape College, Hunan Agricultural University, Changsha, P. R. China.
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  •  Received: 25 March 2016
  •  Accepted: 03 August 2016
  •  Published: 25 August 2016

Abstract

A number of reports have been focusing on chemical compositions and functional properties of essential oils isolated from mint. However, there is little data available on the biological activities of non-volatile constituents. In this study, the antibacterial (against 2 gram-positive bacterial strains: Staphylococcus aureus and Bacillus cereus; 2 gram-negative bacterial strains: Escherichia coli and Pseudomonas aeruginosa), antifungal (against Candida albicans, Colletotrichum gloeosporioides and Penicillium polonicum) and cytotoxic (against Human Embryonic Kidney 293 cell line) activities of three non-volatile extracts (Extracts 1 to 3) from the leaves and stems of mint were evaluated. Extract 1 showed significant antibacterial activity against gram-positive pathogens S. aureus and B. cereus, with an inhibition zone of 12.60 and 12.08 mm, respectively. The minimal inhibitory concentration (MIC) of extract 1 against S. aureus was 0.94 mg/ml. On the other hand, it exhibited low cytotoxic activity against normal Human Embryonic Kidney 293 cell line (CI50 nearly 30 mg/ml), which suggested that Extract 1 could be a potential and safe antibacterial agent. Nevertheless, the tested gram-negative bacteria and pathogenic fungi were not susceptible towards Extracts 2 and 3. 

Key words: Mint, antibacterial activity, antifungal activity, cytotoxicity.