Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3778

Full Length Research Paper

Antibacterial and anti-adhesion activity of the pentacyclic triterpenoids isolated from the leaves and edible fruits of Carissa macrocarpa

Roshila Moodley1*, Hafizah Chenia2, Sreekanth B. Jonnalagadda1 and Neil Koorbanally1
1School of Chemistry, University of KwaZulu-Natal, Durban 4000, South Africa. 2School of Biochemistry, Genetics and Microbiology, University of KwaZulu-Natal, South Africa.
Email: [email protected]

  •  Accepted: 18 July 2011
  •  Published: 23 September 2011

Abstract

Four pentacyclic oleanane triterpenes (β-amyrin, methyl oleanolate, oleanolic acid and 3β-hydroxyolean-11-en-28,13β-olide) were isolated from the fruits of Carissa macrocarpawhilst the ursane triterpene, ursolic acid, was isolated from the leaves. 3 β-hydroxyolean-11-en-28,13β-olide has only been found once previously (in the Lamiaceae) and its lactone ring, which contributes significantly to the expression of antibacterial activity in oleanane triterpenes, makes it an interesting molecule for synthetic and biological studies. The immune boosting properties of the triterpene rich edible fruits of C. macrocarpa are important, especially in South Africa, due to high incidences of Human immunodeficiency virus (HIV) and hepatitis in this country.

 

Key words: Carissa macrocarpa, amatungula, oleanane triterpenes, ursolic acid.