Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3564

Full Length Research Paper

Inhibitory effects on α-glucosidase and hypoglycemic effects of the crude polysaccharides isolated from 11 edible fungi

Chun Xiao1,2,4, Qingpin Wu2*, Jianbin Tan3, Wen Cai3, Xiaobing Yang2 and Jumei Zhang2
1South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. 2Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,Guangdong Open Laboratory of Applied Microbiology, State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base),South China, Guangdong Institute of Microbiology, Guangzhou 510070, China. 3Department of Toxicology, the Center for Disease Control and Prevention of Guangdong Province, Guangzhou 510020, China. 4Graduate School of the Chinese Academy of Sciences, Beijing 100049, China.
Email: [email protected], [email protected]

  •  Accepted: 18 October 2011
  •  Published: 30 December 2011


This objective of this study was to investigate the inhibitory effect of polysaccharides extracted from 11 edible fungi on α-glucosidase in vitro and their hypoglycemic effect in type 2 diabetic mellitus (DM) mice. In vitro, α-glucosidase activity was determined by measuring the p-nitrophenol released from p-Nitrophenyl-α-D-Glucopyranoside at 400 nm. In vivo,Kunming mice with steptozotocin-induced combination high fat diet fed were used. At the end of the study, blood serum glucose and insulin of the mice were measured. In vitro, the crude polysaccharides of Phellinus igniarius and Phellinus chrysoloma showed strong α-glucosidase inhibitory activities of 79.72 and 89.26 %, respectively. In vivo, Serum glucose levels significantly differed (P < 0.01) between the polysaccharides dose-treated groups and the DM group. Grifola frondosa crude polysaccharides showed the greatest hypoglycemic effect in lowering the diabetic blood serum glucose level by 50.09%. The crude polysaccharides of Ganaderma lucidum, Ganaderma sinense, G. frondosa, P. igniarius and P. chrysoloma significantly increased the insulin sensitivity index (ISI) compared with the DM group (P < 0.05). The crude polysaccharides of P. igniarius and P. chrysoloma demonstrated high α-glucosidase inhibitory activities. All 11 edible fungi polysaccharides significantly decreased the fasting serum glucose level in type 2 DM mice. Furthermore, G. lucidum, G. sinense, G. frondosa, P. igniarius and P. chrysoloma crude polysaccharides were able tofacilicate the utilization of insulin and improve insulin resistance.


Key words: Edible fungi, polysaccharides, hypoglycemic activity, type 2 diabetes mellitus mice, α-glucosidase inhibitory activity.

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