Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3596

Full Length Research Paper

Bioactivity of the phytoconstituents of the leaves of Persea americana

M. A. Owolabi 1*, H. A. B. Coker 1 and S. I. Jaja2
1Natural Product Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, College of Medicine Campus, University of Lagos, Lagos, Nigeria.  2Department of Physiology, College of Medicine, University of Lagos, P. M. B. 12003, Lagos, Nigeria.
Email: [email protected]

  •  Accepted: 09 June 2010
  •  Published: 18 June 2010

Abstract

Isolation of the bioactive phytoconstituents of the leaves of Persea americana(Lauraceae), yielded, isorhamnetin (1), luteolin (2), rutin (3), quercetin (4) and apigenin (5). Compound 1 has been fully characterized. Compounds were evaluated for their ability to scavenge free radical using DPPH· and H2O2systems. The IC50 (mg/ml) of quercetin was 4.82 x 10-5; rutin, 1.37 x 10-4; luteolin, 3.34 x 10-4 and isorhamnetin, 4.41 x 10-4. H2Oscavenging activity of the compounds was quercetin > rutin > isorhamnetin > luteolin > apigenin > BHA (p > 0.05). From this study it could be concluded that the leaves of P. americanacontain antioxidant activity which may be helpful in preventing the progress of various oxidative stress related diseases.

 

Key words: Persea americana, Lauraceae, flavonols, antioxidant activity, oxidative stress, radical scavenging. 

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