Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3830

Full Length Research Paper

Hepatoprotective activity of aqueous extract of Khaya senegalensis bark in rats

S. A. M. Ali, S. M. A. ElBadwi*, T. M. Idris and K. M. Osman
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Khartoum, Sudan.
Email: [email protected]

  •  Accepted: 09 September 2011
  •  Published: 30 October 2011

Abstract

This study was designed to evaluate the hepatoprotective activity of Khaya senegalensis bark (Meliaceae) against CCl4- induced liver damage in rats. Aqueous extract of the bark of K. senegalensis was orally administered to rats at 250 and 500 mg/kg for five days which was significantly alleviate the damage that induced to liver by CCL4. The levels of AST, ALT, ALP, bilirubin, total protein and albumin, in groups treated by extract were significantly decreased compared to CCL4 group. These findings were strongly confirmed by histopathological studies of liver tissue in comparison with the group treated by the standard drug silymarin. This study indicates that, the aqueous extract of K. senegalensis bark possesses hepatoprotective ingredients.

 

Key words: Khaya senegalensis, hepatoprotective activity, Silymarin, carbon tetrachloride.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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