Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3793

Full Length Research Paper

A study to assess the plaque inhibitory action of herbal-based toothpaste: A double blind controlled clinical trial

Golpar Radafshar1*, Faranak Mahboob2 and Ehsan Kazemnejad2
1Department of Periodontology, Faculty of Dentistry, Dental Research Center,  Guilan University of Medical Sciences, Rasht, Iran. 2Dental Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Email: [email protected]

  •  Accepted: 10 June 2010
  •  Published: 18 June 2010


Incorporating herbal extracts in the formulation of toothpastes is becoming an accepted mode of chemical plaque control. This study has been conducted to determine whether an herbal-based toothpaste would inhibit de novo plaque formation beyond that of a conventional fluoride Toothpaste. Fifteen adult volunteers, meeting the inclusion criteria (age range19 - 22) participated in a double-blind, cross-over controlled clinical trial, based on a variation of a 4 day plaque regrowth model. After professional tooth cleaning, subjects were asked to refrain from all mechanical hygiene measures for the next 96 h, and  to use two rinses (1 min) a day as the only oral hygiene measure. At day 4, teeth were stained to assess the whole mouth plaque index (PI) using Turesky modification of Quigley Hein PI (TMQH), and to evaluate the PI for anterior teeth using a 10 scaled method of plaque scoring (NMPS). Herbal-based toothpaste provided statistically significant plaque inhibitory action measured by whole mouth plaque index, over control toothpaste (P = 0.032). There was no significant difference between test and control dentifrices in plaque index for anterior teeth using NMPS index. Pearson´s correlation coefficient showed significant values indicating close similarity between the two indices (r = 0.962, P < 0.0001). This study demonstrated the effectiveness of herbal-based toothpaste in the control of dental plaque formation over control paste. Further investigation into the potential value of this formulation among target population is recommended.


Key words: Plaque inhibition, herbal based toothpaste, clinical trial, plaque index.