Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3727

Full Length Research Paper

Aphrodisiac activity of ethanol extract and fractions of Fadogia cienkowskii Shweinf. Rubiaceae roots in albino rats

Jurbe Gofwan Gotep
  • Jurbe Gofwan Gotep
  • Drug Development Division, National Veterinary Research Institute, Vom, Plateau State, Nigeria.
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Sunday Yakubu Sabo
  • Sunday Yakubu Sabo
  • Pharmacology and Toxicology Department, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria.
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Sunday Makama
  • Sunday Makama
  • Biochemistry Division, National Veterinary Research Institute, Vom, Plateau State, Nigeria.
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Mary Ogonnaya Uguru
  • Mary Ogonnaya Uguru
  • Pharmacology and Toxicology Department, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria.
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Francis Kanayo Okwuasaba
  • Francis Kanayo Okwuasaba
  • Pharmacology and Toxicology Department, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria.
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  •  Accepted: 01 February 2020
  •  Published: 28 February 2021

Abstract

Fadogia cienkowskii is a shrub whose roots are used in many communities of Northern Nigeria to improve sexual performance; however, there is no scientific study to verify this claim. This study determined the effect of 70% ethanol extract of F. cienkowskii roots and its fractions (ethyl acetate, n-butanol, and residual ethanol) on mating behaviour (mounting, intromission and ejaculation) and serum testosterone concentration of male albino rats. Five groups of rats each containing 6 rats were treated with 50, 100 and 200 mg/kg of the crude ethanol extract, while Sildenafil and distilled water were administered to the control groups. Another set of 6 groups of rats were also used in the study and were treated with 12.5 and 25 mg/kg of the ethyl acetate, n-butanol and residual ethanol fractions, respectively. The crude extract and fractions significantly increased mount, intromission and ejaculation frequencies. The copulation efficiency also increased significantly – indicative of the plant’s aphrodisiac potential. Significant increase of testosterone in serum of extract treated rats was also observed, which is a further credence to the plant’s aphrodisiac potential. It was thus concluded that the 70% ethanol root extract of F. cienkowskii and its fractions have aphrodisiac activity with the n-butanol and residual ethanol fractions being more active.

Key words: Fadogia cienkowskii extract, aphrodisiac activity, rats