The methanolic extract of the stems of Montanoa bipinnatifida was investigated for its phenolic compounds and hepactoprotective activity. A new flavon C-glycosides named as luteolin 6-C- apioside 8-C- glucoside (1) as well as apigenin 6-C-glucoside(2), apigenin 8-C-glucoside(3), apigenin 6,8- di-C-glucoside(4), luteolin 8-C-glucoside(5) luteolin 6,8- di-C-glucoside(6), luteolin 6-C- glucoside(7), apigenin(8) and luteolin(9) were isolated from the M. bipinnatifida stems aqueous alcoholic extract. Structures of the isolated compounds were established by chromatography, UV and 1Dâˆ•2D 1Hâˆ• 13C spectroscopy. Hepatoprotective and antioxidant effects were investigated for the aqueous methanol extract of M. bipinnatifida stems (100 and 150mg/Kg b.wt.) in normal and carbon tetrachloride –hepatic damaged rats. The hepatotoxic dose of CCl4 (25 mg/Kg, orally) raised significantly (P< 0.05) the serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels as compared to control values. The dose aqueous methanolic extract of M. bipinnatifida stems were able to prevent CCl4-induced rise in serum enzymes.
Key words: Montanoa bipinnatifida, flavone-C-glycosides, CCl4, hepatoprotective.
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