Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3824

Full Length Research Paper

Flavone C-glycosides from Montanoa bipinnatifida stems and evaluation of hepatoprotective activity of extract

Sayed A. El-Toumy1*, Enayat A. Omara2, Somaia A. Nada3 and Jame Bermejo4
1Chemistry of Tannins Department, National Research Centre, El-Bohouth Str., Dokki, 12311 Cairo, Egypt. 2Department of Pathology, National Research Centre, El-Bohouth Str., Dokki, 12311 Cairo, Egypt. 3Department of Pharmacology National Research Centre, El-Bohouth Str., Dokki, 12311 Cairo, Egypt. 4Instituto de Productos Naturales y Agrobiología, Av.Astrofisico F. Sanchez 3, 38206 La Laguna, Tenerife, Spain.
Email: [email protected]

  •  Accepted: 18 September 2010
  •  Published: 18 April 2011


The methanolic extract of the stems of Montanoa bipinnatifida was investigated for its phenolic compounds and hepactoprotective activity. A new flavon C-glycosides named as luteolin 6-C- apioside 8-C- glucoside (1) as well as apigenin 6-C-glucoside(2), apigenin 8-C-glucoside(3), apigenin 6,8- di-C-glucoside(4), luteolin 8-C-glucoside(5) luteolin 6,8- di-C-glucoside(6), luteolin 6-C- glucoside(7), apigenin(8) and luteolin(9) were isolated from the M. bipinnatifida stems aqueous alcoholic extract. Structures of the isolated compounds were established by chromatography, UV and 1D∕2D 1H∕ 13C spectroscopy. Hepatoprotective and antioxidant effects were investigated for the aqueous methanol extract of M. bipinnatifida stems (100 and 150mg/Kg b.wt.) in normal and carbon tetrachloride –hepatic damaged rats. The hepatotoxic dose of CCl4 (25 mg/Kg, orally) raised significantly (P< 0.05) the serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels as compared to control values. The dose aqueous methanolic extract of M. bipinnatifida stems were able to prevent CCl4-induced rise in serum enzymes.


Key words: Montanoa bipinnatifida, flavone-C-glycosides, CCl4, hepatoprotective.