Abstract

Ejaculation is a complex physiological and psychological process which cholinergic and dopaminergic mechanisms might be involved in regulation of it. Rapid ejaculation is the most frequently encountered sexual complaint of men and different method of treatments were recommended. The aim of this study was to investigate possible role of the methanolic extracts of the Boswellia serrata and Lavandula angustifolia on ejaculatory responses induced by apomorphine in male Wistar rats. Ejaculation was induced by subcutaneous injection of apomorphine dissolved in saline and was counted by direct observation after drug injection. The effects of methanolic extracts of B. serrataand L. angustifolia on apomorphine induced ejaculation were examined. The results showed dose related decrease of semen drop numbers due to extracts administration. During monotherapy the effective doses of both extracts were 100 mg/kg. Combination therapy with both B. serrate and L. angustifolia extracts (50,100 mg/kg) significantly decreased semen drop numbers. It was concluded that, mono/combination therapy with B. serrate and L. angustifolia extracts decreased apomorphine - induced ejaculation and may have a beneficial role in the treatment of rapid ejaculation.

Key words: Ejaculation, apomorphine, sexual behavior, herbal.