Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3840

Full Length Research Paper

Tribulus terrestris inhibits caries-inducing properties of Streptococcus mutans

Hong-Keun Oh1, Soo Jeong Park1, Hae Dalma Moon2, Seung Hwan Jun2, Na-Young Choi3 and Yong-Ouk You2*
1College of Alternative Medicine, Jeonju University, Jeonju, South Korea. 2Department of Oral Biochemistry, School of Dentistry, Wonkwang University, Iksan, South Korea. 3College of Education Wonkwang University, Iksan, South Korea.
Email: [email protected]

  •  Accepted: 09 September 2011
  •  Published: 09 November 2011

Abstract

In the present study, we examined the inhibitory effects of the ethanol extract of Tribulus terrestris on the growth, acid production, adhesion, and water-insoluble glucan synthesis ofStreptococcus mutans. The growth and acid production of S. mutans were significantly inhibited in the presence of the ethanol extract of T. terrestris (0.1 to 0.5 mg/ml). The ethanol extract of T. terrestris (0.1 to 0.5 mg/ml) also significantly lowered the adherence of S. mutansin a dose-dependent manner. In the water-insoluble glucan synthesis assay, 0.025 to 0.5 mg/ml of the ethanol extract of T. terrestris significantly inhibited the formation of water-insoluble glucans. These results suggest that T. terrestris may inhibit the caries-inducing properties of S. mutans. Further studies are necessary to clarify the active constituents of T. terrestris responsible for such biomolecular activities.

 

Key words: Tribulus terrestris, acid production, adhesion, water-insoluble glucan,Streptococcus mutans.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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