Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3672

Full Length Research Paper

Antibacterial activity of extracts of Stevia rebaudiana Bertoni against Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa

Mariana Miranda-Arámbula
  • Mariana Miranda-Arámbula
  • Centro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional (CIBA-IPN), México
  • Google Scholar
Maricruz Olvera-Alvarado
  • Maricruz Olvera-Alvarado
  • Facultad de Ciencias Químicas, Departamento de Bioquímica-Alimentos, Benemérita Universidad Autónoma de Puebla, Ciudad Universitaria, Col. San Manuel, C.P. 72570 Puebla, Pue., México.
  • Google Scholar
Marta Lobo-Sánchez
  • Marta Lobo-Sánchez
  • Facultad de Ciencias Químicas, Departamento de Bioquímica-Alimentos, Benemérita Universidad Autónoma de Puebla, Ciudad Universitaria, Col. San Manuel, C.P. 72570 Puebla, Pue., México.
  • Google Scholar
Ivonne Pérez-Xochipa
  • Ivonne Pérez-Xochipa
  • Facultad de Ciencias Químicas, Departamento de Bioquímica-Alimentos, Benemérita Universidad Autónoma de Puebla, Ciudad Universitaria, Col. San Manuel, C.P. 72570 Puebla, Pue., México.
  • Google Scholar
Ada María Ríos-Cortés
  • Ada María Ríos-Cortés
  • Centro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional (CIBA-IPN), México
  • Google Scholar
Sandra Luz Cabrera-Hilerio
  • Sandra Luz Cabrera-Hilerio
  • Facultad de Ciencias Químicas, Departamento de Bioquímica-Alimentos, Benemérita Universidad Autónoma de Puebla, Ciudad Universitaria, Col. San Manuel, C.P. 72570 Puebla, Pue., México.
  • Google Scholar


  •  Received: 18 March 2017
  •  Accepted: 18 May 2017
  •  Published: 03 July 2017

Abstract

Plants have been an important source of secondary metabolites known for their diverse biological activities; some have been shown to inhibit the development of certain pathogenic microorganisms. Herein, the antimicrobial activity of the carbon tetrachloride, hexane, ethanol, and aqueous extracts of leaves of Stevia rebaudiana Bertoni against Staphylococcus aureus (strain 921), Staphylococcus epidermidis (strains 965, 982, and 735), and Pseudomonas aeruginosa (strains RO3 and RO4) was presented. The antibacterial activity was evaluated using the disk diffusion method, and the minimal inhibitory concentration (MIC) was determined. The results show that, even at the lowest evaluated concentration (1.06 mg/mL), the hexane extract had an inhibitory effect for all the studied microorganisms. The aqueous extract exhibited high inhibition values (84.4%), on S. epidermidis (strain 965). These results indicate that compounds contained in non-polar extracts of S. rebaudiana could be potential candidates as conventional pharmaceutical drugs against bacteria, resistant to conventional antibiotics.

Key words: Stevia rebaudiana, antimicrobial properties, plant extracts.