Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Activities of Guatemalan medicinal plants against cancer cell lines and selected microbes: Evidence for their conservation

Rex G. Cates*
  • Rex G. Cates*
  • College of Life Sciences, Brigham Young University (BYU), Provo, UT USA.
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Andrew Thompson
  • Andrew Thompson
  • College of Life Sciences, Brigham Young University (BYU), Provo, UT USA.
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Holly Brabazon
  • Holly Brabazon
  • College of Life Sciences, Brigham Young University (BYU), Provo, UT USA.
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Sidney McDonald
  • Sidney McDonald
  • College of Life Sciences, Brigham Young University (BYU), Provo, UT USA.
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Michael Lawrence
  • Michael Lawrence
  • College of Life Sciences, Brigham Young University (BYU), Provo, UT USA.
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Steven Williams
  • Steven Williams
  • College of Life Sciences, Brigham Young University (BYU), Provo, UT USA.
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Pablo Peniallilo
  • Pablo Peniallilo
  • College of Life Sciences, Brigham Young University (BYU), Provo, UT USA.
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J. Alfonso Fuentes Soria
  • J. Alfonso Fuentes Soria
  • Secretaría General del Consejo Superior Universitario Centroamericano (CSUCA), Ave. Las Americas 1-03, Zona No. 14, Interior Club Los Arcos, Guatemala City, Guatemala.
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Luis V. Espinoza
  • Luis V. Espinoza
  • Benson Agriculture and Food Institute, Brigham Young University (BYU), Provo, UT USA.
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José Vicente Martinez
  • José Vicente Martinez
  • Facultad de Agronomia, Universidad de San Carlos de Guatemala (USAC), Guatemala City, Guatemala.
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Dany A. Arbizú
  • Dany A. Arbizú
  • Benson Institute Guatemala, Chiquimula, Guatemala.
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Ernesto Villagran
  • Ernesto Villagran
  • Facultad de Odontología, Area Socio-Preventiva, Universidad de San Carlos de Guatemala (USAC), Guatemala City, Guatemala.
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Fernando Ancheta
  • Fernando Ancheta
  • Facultad de Odontología, Area Socio-Preventiva, Universidad de San Carlos de Guatemala (USAC), Guatemala City, Guatemala.
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  •  Received: 09 June 2014
  •  Accepted: 19 August 2014
  •  Published: 03 September 2014

Abstract

Medicinal plants are important components in the primary health care of villagers in Guatemala.  However, an area often overlooked is the effect of medicinal plants on oral hygiene.  Acetone and methanol extracts from 63 medicinal plant species from 31 families were bioassayed against breast, cervical, skin and tongue cancers, and the following microorganisms: Staphylococcus aureus, Escherichia coli, Streptococcus mutans, Lactobacillus acidophilus and Candida albicans.  Half-maximum inhibitory concentrations (IC50) and half-maximum cytotoxicity concentrations (CC50) were determined against cancerous and non-cancerous cell lines, respectively.  Minimum inhibitory concentrations (MIC) were determined against microbes. Based on levels of inhibition by extracts, IC50 values, CC50 values, and MIC values, seven species (Bursera simaruba Sarg., Burseraceae; Eriobotrya japonica (Thumb.) Lindl., Rosaceae; Litsea guatemalensis Mez, Lauraceae; Mirabilis jalapa L., Nyctaginaceae; Pithecellobium dulce (Roxb.) Benth., Fabaceae); Rubus villosus Thunb., Rosaceae; Thevetia peruviana K. Schum., Apocynaceae) were recommended for additional investigation. With regard to oral hygiene four species (Achillea millefolium L., Asteraceae; Crotalaria longirostrata Hook. and Arn., Fabaceae; P. dulce; Spondias purpurea L., Anacardiaceae) may merit further fractionation and testing against oral diseases.   

 

Key words: Anticancer, antimicrobial, IC50, CC50, MIC, oral hygiene, Guatemala.