Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3743

Full Length Research Paper

Evaluation of the biological activities of leaf and bark extracts of Ficus platiphylla Delile, a medicinal plant used in Mali

Mamadou Abdoulaye Konaré
  • Mamadou Abdoulaye Konaré
  • Laboratory of Plant and Food Biochemistry and Biotechnologies (LBVA_B), Faculty of Sciences and Techniques (FST), University of Sciences, Techniques and Technologies of Bamako (USTTB), Mali –BPE 3206.
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Nouhoum Diarra
  • Nouhoum Diarra
  • Laboratory of Plant and Food Biochemistry and Biotechnologies (LBVA_B), Faculty of Sciences and Techniques (FST), University of Sciences, Techniques and Technologies of Bamako (USTTB), Mali –BPE 3206.
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Cheickna Cissé
  • Cheickna Cissé
  • Laboratory of Plant and Food Biochemistry and Biotechnologies (LBVA_B), Faculty of Sciences and Techniques (FST), University of Sciences, Techniques and Technologies of Bamako (USTTB), Mali –BPE 3206.
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Daouda Abdoul Karim Traoré
  • Daouda Abdoul Karim Traoré
  • Laboratory of Plant and Food Biochemistry and Biotechnologies (LBVA_B), Faculty of Sciences and Techniques (FST), University of Sciences, Techniques and Technologies of Bamako (USTTB), Mali –BPE 3206.
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Issiaka Togola
  • Issiaka Togola
  • Laboratory of Plant and Food Biochemistry and Biotechnologies (LBVA_B), Faculty of Sciences and Techniques (FST), University of Sciences, Techniques and Technologies of Bamako (USTTB), Mali –BPE 3206.
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Adounigna Kassogué
  • Adounigna Kassogué
  • Microbiology and Microbial Biotechnology Laboratory (LaBoREM-Biotech), Faculty of Sciences and Techniques (FST), University of Sciences, Techniques and Technologies of Bamako (USTTB), BPE 3206, Mali.
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Rokia Sanogo
  • Rokia Sanogo
  • Department of Traditional Medicine (DMT), National Institute of Research in Public Health (INSRP), B.P 1746 Bamako, Mali.
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Aboubacar Sidiki Ouattara
  • Aboubacar Sidiki Ouattara
  • Research Centre for Biological Food and Nutritional Sciences (CRSBAN), University Joseph Ki-Zerbo, 03 BP 7131 Ouagadougou 03, Burkina Faso.
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  •  Received: 02 November 2019
  •  Accepted: 14 February 2020
  •  Published: 31 March 2020

Abstract

Leaves and barks of Ficus platiphylla are used in traditional medicine in western Africa for treating bacterial infections. The aim of this work was to screen the biological activities of extracts of the plant. Three common bacterial strains were used in this study. The antiradical and antibacterial activities were assessed respectively by spectrophotometric and agar diffusion methods. The bark and leaves are very rich in dry matter, ash and as well as proteins and carbohydrates. Ethyl acetate was the best solvent to extract polyphenols (4.77-5.01 g/100 g) and flavonoids (1.97-3.32 g/100 g). Similarly, ethyl acetate extracts showed the best anti-free radical activity with IC50 = 5.10 and 5.22 µg/ml for bark and leaves respectively. The aqueous and methanolic leaf extracts displayed the highest antibacterial activity on the Escherichia coli, with an inhibition diameter (ID) of 11.50 ± 0.50 mm. On Salmonella typhi, the most active antibacterial agents were found in leaf ethyl acetate extracts with ID = 15.33 ± 0.58 mm. These extracts have the same efficacy as the commercial antibiotic ciprofloxacin (positive control) which displayed an ID of 15.33 ± 0.76 mm. Finally, S. aureus was highly sensitive to ethyl acetate extracts of the barks: ID = 15.50 ± 1.32 mm (p-value = 4.10E-6 < 0.05). The richness in secondary metabolites associated with the antiradical and antibacterial activities justify use of F. platiphylla in traditional medicine. This study shows that F. platiphylla could be a valuable medicinal plant for the management of common bacterial infections.

Key words: Ficus platiphylla extracts, phytochemical screening, antiradical activity, antibacterial activity.