Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3621

Full Length Research Paper

Evaluation of prunes for hypotensive, angiotensin converting enzyme (ACE) inhibitory and diuretic activities in rats

Qaiser Jabeen1, Naveed Aslam1, 2*, Adnan Akram1 and Zafar Iqbal1
1Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Pakistan. 2Department of Health, Government of the Punjab, District Bahawalpur, Pakistan.
Email: [email protected]

  •  Accepted: 22 December 2011
  •  Published: 23 February 2012

Abstract

Prunes are dried fruits of several species of Prunus, including that of Prunus domestica Linn (Rosaceae) and are used for the treatment of hypertension in traditional systems of medicine in India and Pakistan. We investigated the blood pressure lowering, angiotensin converting enzyme (ACE) inhibitory and diuretic activities of the aqueous-methanolic crude extract of dried fruits of P. domestica (Pd.Cr.) in rats. Intravenous administration of the Pd Cr decreased mean arterial blood pressure, systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the ketamine-diazepam anesthetized normotensive rats dose-dependently, at the dose range of 1 to 30 mg/kg. In vitro, the extract was fond to have serum ACE inhibitory activity, with IC50value of 1.102 mg/ml. The extract did not increase urine output in rats. The study concludes that the crude extract of prunes has hypotensive and ACE inhibitory activities, which provides scientific justification for its traditional uses as cardioprotective and antihypertensive remedy.

 

Key words: Prunes, Prunus domestica, hypotensive, angiotensin converting enzyme (ACE) inhibition, diuretic.

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