Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3843

Full Length Research Paper

Antiproliferative activity of aqueous extract of Piper betle L. and Psidium guajava L. on KB and HeLa cell lines

A.R.Fathilah1*, R.Sujata2, A.W.Norhanom2 and M.I.Adenan3
1Department of Oral Biology, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. 2Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. 4Malaysia Institute of Pharmaceuticals and Nutraceuticals, 11900 Bukit Jambul, Penang, Malaysia.
Email: [email protected]

  •  Accepted: 08 February 2010
  •  Published: 04 June 2010

Abstract

The aim of the present study was to assess the effect of the aqueous extracts ofPsidium guajava and Piper betle plants on the proliferation of cancerous cell lines, that is KB and HeLa cell line. Using the neutral red cytotoxicity assay, the IC50 of P. guajava and P. betle were determined at 29.0 ± 0.4 and 29.5 ± 0.3 µg/ml, respectively, indicating both plant extracts equally potent for the treatment of cancerous oral epidermal lesions. However, a less potent anti - proliferative activity was recorded by P. guajava towards HeLa cell line with an IC50 of 51.0 ± 0.6 µg/ml, whereas P. betle extract did not affect the proliferation of HeLa.

 

Key words: Antiproliferative, KB cells, heLa cells, Psidium guajava, Piper betle.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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