Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3830

Full Length Research Paper

Cytotoxic effect of Typhonium flagelliforme extract

Nobakht, G. M.*
  • Nobakht, G. M.*
  • Department of Agriculture Technology, Faculty of Agriculture, University Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia.
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Kadir, M. A
  • Kadir, M. A
  • Department of Agriculture Technology, Faculty of Agriculture, University Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia.
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Stanslas, J
  • Stanslas, J
  • Department of Medicine, Faculty of Medicine and Health Science, University Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia.
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Charng, C. W
  • Charng, C. W
  • Department of Medicine, Faculty of Medicine and Health Science, University Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia.
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  •  Received: 13 July 2011
  •  Accepted: 07 December 2011
  •  Published: 31 August 2014

Abstract

 

Traditionally,Typhonium flagelliforme is used to treat cancer in Malaysia, People take it as powder or in combination with milk or different types of other herbal extracts as treatment of different type of cancers (Teo and Chang, 1996). The study was conducted to determine anticancer activity of crude extract of 1 to 6 months old ex-vitro plantlets and one sample of in vitro plants of T. flagelliforme against MCF-7 human breast cancer cell lines. The growth inhibitory activity was tested by GI50 (the concentration of drugs which inhibited the cell growth by 50%). Extracts of 2, 3, 4, 5, 6 months old field grown plants, was found to be actice against MCF-7 with the GI50 values of 6.2, 33.1, 14.7, 57.5, 16.6 µg/ml respectively.

 

Key words: Typhonium flagelliforme, cytotoxic effect, traditional medicine.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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