Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3761

Full Length Research Paper

Gastroprotective effects of amygdalin on experimental gastric ulcer: Role of NO and TNF-α

Fatemeh Nabavizadeh1*, Ali Mohammad Alizadeh2, Zahra Sadroleslami1 and  Soheila Adeli1
1Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran. 2Cancer Research Center, Tehran University of medical sciences, Tehran, Iran.
Email: [email protected]

  •  Accepted: 19 April 2011
  •  Published: 18 July 2011

Abstract

Natural plant origin products like amygdalin with anti-inflammatory effects are still a major part of traditional medicine. We conducted the present investigation to elucidate the amygdalin effects on alcohol-induced gastric ulcer together with the possible role of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). Thirty-two male Wistar rats were used to study therapeutic and preventive effects of amygdalin on absolute alcohol-induced gastric ulcer. Animals were equally divided into 4 groups (n=8): (I) control, (II) Alcohol; absolute alcohol (1 ml/200 g b.w) used to induce gastric ulcer, (III) Alcohol/Amygda; amygdalin (2 mg/kg/day intramuscular) administrated for three weeks after gastric ulcer induction and (IV) Amygda/Alcohol; amygdalin was given for three weeks before gastric ulcer induction. Ulcer index, gastric acid secretion, gastric tissue’s NO metabolites andTNF-α level measured. Ulcer index was significantly decreased in Alcohol/Amygda than Alcohol group (p<0.05). Gastric tissue’s NO metabolites level and gastric acid secretion decreased in Alcohol and Amygda/Alcohol groups than control (p<0.05). Gastric tissue TNF-α level increased in Alcohol and Amygda/Alcohol rats than control group (p<0.05). The results of this study show that amygdalin protected gastric mucosa from alcohol-induced gastric ulcer. This gastroprotection may mediate via gastric mucosal nitric oxide production and TNF-α suppression.

 

Key words: Amygdalin, gastric ulcer, nitric oxide, TNF-α.