Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3649

Full Length Research Paper

In vitro preliminary study of antiprotozoal effect of four medicinal plants from Benin

Latifou LAGNIKA1*, Barthélémy ATTIOUA2, Catherine VONTHRON-SENECHEAU3, Marcel KAISER4, Annelise LOBSTEIN3, Ambaliou SANNI1 and Bernard WENIGER3    
1Laboratoire de Biochimie et de Biologie Moléculaire, Département de Biochimie et de Biologie Cellulaire, Université d’Abomey-Calavi, Bénin. 2Laboratoire de Chimie Organique Biologique, UFR Sciences des Structures de la Matière et Technologie, Université de Cocody, Abidjan, Côte d'ivoire. 3Laboratoire de Pharmacognosie et Molécules Naturelles Bioactives, Laboratoire d’Innovation Thérapeutique, UMR CNRS-UdS 7200, Faculté de Pharmacie, Université de Strasbourg, France. 4Swiss Tropical and Public Health Institution, Socinstrasse 57, 4002 Basel, Switzerland. University of Basel, Basel, Switzerland.    
Email: [email protected]

  •  Accepted: 22 March 2012
  •  Published: 10 March 2013

Abstract

A total of fourteen extracts with different polarity obtained from four species Crataeva religiosa, Baillonella toxisperma, Boswellia dalzielii and Khaya senegalensis, traditionally used in Benin to treat malaria were tested for their in vitro antiprotozoal activity towardsPlasmodium falciparum, Trypanosoma rhodesiense, Trypanosoma cruzi and Leishmania donovani. Selected plants were extracting with cyclohexane, methylene chloride, ethyl acetate, ether diethyl, methanol and ethanol. Tested extracts showed moderate to good antiparasitic effects at two different concentrations (9.6 and 1.6 µg/ml). Many extracts showed appreciable growth inhibition at 9.5 µg/ml. Ethanol extract of B. dalzielii was the most active against T. rhodesiense and L. donovani with growth inhibition percentage of 100 and 95.6%, respectively. Seven out of fourteen extracts also showed interesting growth inhibition percentage from 99 to 87%, on P. falciparum at 9.6 µg/ml. The most interesting activity against L. donovani was observed with the cyclohexane extract of C. religiosa with growth inhibition value of 55% at 1.6 µg/ml.

 

Key words: Traditional medicine, antimalarial, leishmanicidal, trypanocidal, Benin.

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