Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3702

Full Length Research Paper

Phytochemical, antioxidant and cytotoxic analysis of Brazilian cerrado plants: Preliminary evidence of their antitumor activity

Thiago Antônio de Sousa Araújo*
  • Thiago Antônio de Sousa Araújo*
  • Universidade Federal de Tocantins- Campus Universitário de Palmas - Quadra 109 Norte, Avenida NS 15 Alameda C NO 14, Bloco: BALA 01, Palmas-TO. CEP: 77001-090, Brazil. 2Universidade Federal de Pernambuco ? Centro de Ciências da Saúde - Departamento de Ciências Farmacêuticas - Laboratório de Produtos Naturais, Rua Prof. Artur de Sá S/N, Cidade Universitária, Recife-PE. CEP: 50740-521, Brazil.
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Tadeu José da Silva Peixoto Sobrinho
  • Tadeu José da Silva Peixoto Sobrinho
  • Universidade Federal de Pernambuco ? Centro de Ciências da Saúde - Departamento de Ciências Farmacêuticas - Laboratório de Produtos Naturais, Rua Prof. Artur de Sá S/N, Cidade Universitária, Recife-PE. CEP: 50740-521, Brazil.
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Jaciana dos Santos Aguiar³
  • Jaciana dos Santos Aguiar³
  • Universidade Federal de Pernambuco - Centro de Ciências da Saúde - Departamento de Antibióticos ? Laboratório de Bioensaios para Pesquisa de Fármacos - Recife - PE CEP: 50670-901, Brazil.
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Ana Carolina Oliveira da Silva
  • Ana Carolina Oliveira da Silva
  • Universidade Federal de Tocantins- Campus Universitário de Palmas - Quadra 109 Norte, Avenida NS 15 Alameda C NO 14, Bloco: BALA 01, Palmas-TO. CEP: 77001-090, Brazil.
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Felipe Uchôa Brito
  • Felipe Uchôa Brito
  • Universidade Federal de Tocantins- Campus Universitário de Palmas - Quadra 109 Norte, Avenida NS 15 Alameda C NO 14, Bloco: BALA 01, Palmas-TO. CEP: 77001-090, Brazil.
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Gonçalves da Silva
  • Gonçalves da Silva
  • Universidade Federal de Pernambuco - Centro de Ciências da Saúde - Departamento de Antibióticos ? Laboratório de Bioensaios para Pesquisa de Fármacos - Recife - PE CEP: 50670-901, Brazil.
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Elba Lucia Cavalcanti de Amorim
  • Elba Lucia Cavalcanti de Amorim
  • Universidade Federal de Pernambuco ? Centro de Ciências da Saúde - Departamento de Ciências Farmacêuticas - Laboratório de Produtos Naturais, Rua Prof. Artur de Sá S/N, Cidade Universitária, Recife-PE. CEP: 50740-521, Brazil.
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Maria Cristina da Silva Pranchevicius1,4
  • Maria Cristina da Silva Pranchevicius1,4
  • 1Universidade Federal de Tocantins- Campus Universitário de Palmas - Quadra 109 Norte, Avenida NS 15 Alameda C NO 14, Bloco: BALA 01, Palmas-TO. CEP: 77001-090, Brazil. 4Universidade Federal de São Carlos ? Departamento de Genética e Evolução. Rod. Washington Luis, km 235 - São Carlos - SP - BR - CEP: 13565-905, Brazil.
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  •  Received: 17 January 2015
  •  Accepted: 26 February 2015
  •  Published: 03 March 2015

Abstract

The aim of this study was to analyze the antitumor activity of Anacardium humile A. St.-Hil., Brosimum gaudichaudii Trécul and Tabebuia avellanedae Lorentz ex Griseb species, which are distributed in the Cerrado region of Brazil. Qualitative and quantitative analyses were also conducted on the bark and leaf extracts and antioxidant and cytotoxic activities were studied. The results showed that the bark and leaf extracts of A. humile exhibited the highest contents of phenolic compounds and optimal antioxidant activity. The leaf extract of T. avellanedae had the highest content of flavonoids, displayed high efficiency as a ferrous ion chelating agent and inhibited the growth of the human laryngeal carcinoma (HEp-2) cell line by 88.0% at the concentration of 50 µg/ml. The leaves of B. gaudichaudii had higher levels of condensed tannins, flavonoids and coumarins compared with that of the bark. There was a correlation between inhibition of the NCI- human lung cancer (H292) cell line and the content of condensed tannins and antiradical activity and also between the inhibition of human colon carcinoma (HT-29) cell growth and the antioxidant and chelating activity of ferrous ion. Our data provide evidence that bark and leaf extracts of A. humile and leaves of T. avellanedae possess anticancer activity; therefore, the isolation and identification of the active ingredients of these plant tissues should be conducted to explore their therapeutic potential.

 

Key words: Antiproliferative, Hep-2 cells, HT-29 cells, medicinal plants, NCI-H292 cells, phenolic compounds.