Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3654

Full Length Research Paper

Systematic review: Medicinal use and scientific elucidation of the Piper genus for the treatment of symptoms and inflammatory diseases

Cícera Norma Fernandes Lima
  • Cícera Norma Fernandes Lima
  • Departamento de Química Biológica (DQB), Universidade Regional do Cariri (URCA), Crato, CE, Brazil.
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Luciene Ferreira de Lima
  • Luciene Ferreira de Lima
  • Departamento de Química Biológica (DQB), Universidade Regional do Cariri (URCA), Crato, CE, Brazil.
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Denise Bezerra Correia
  • Denise Bezerra Correia
  • Departamento de Química Biológica (DQB), Universidade Regional do Cariri (URCA), Crato, CE, Brazil.
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Sara Tavares de Sousa Machado
  • Sara Tavares de Sousa Machado
  • Departamento de Química Biológica (DQB), Universidade Regional do Cariri (URCA), Crato, CE, Brazil.
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Jéssica Pereira de Sousa
  • Jéssica Pereira de Sousa
  • Departamento de Química Biológica (DQB), Universidade Regional do Cariri (URCA), Crato, CE, Brazil.
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Enaide Soares Santos
  • Enaide Soares Santos
  • Departamento de Química Biológica (DQB), Universidade Regional do Cariri (URCA), Crato, CE, Brazil.
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Gyllyandeson de Araújo Delmondes
  • Gyllyandeson de Araújo Delmondes
  • Departamento de Química Biológica (DQB), Universidade Regional do Cariri (URCA), Crato, CE, Brazil.
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Irwin Rose Alencar de Menezes
  • Irwin Rose Alencar de Menezes
  • Departamento de Química Biológica (DQB), Universidade Regional do Cariri (URCA), Crato, CE, Brazil.
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Cícero Francisco Bezerra Felipe
  • Cícero Francisco Bezerra Felipe
  • Departamento de Biologia Molecular (DBM), Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brazil.
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Henrique Douglas Melo Coutinho
  • Henrique Douglas Melo Coutinho
  • Departamento de Química Biológica (DQB), Universidade Regional do Cariri (URCA), Crato, CE, Brazil.
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Marta Regina Kerntopf
  • Marta Regina Kerntopf
  • Departamento de Química Biológica (DQB), Universidade Regional do Cariri (URCA), Crato, CE, Brazil.
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  •  Received: 30 September 2019
  •  Accepted: 21 November 2019
  •  Published: 29 February 2020

Abstract

The aim of this study was to conduct a systematic review that reported the medicinal use of the genus Piper, and pharmacological elucidations for the treatment of symptoms and processes of inflammation and inflammatory diseases. The systematic review was prepared in accordance with PRISMA guidelines. The databases used for this research were the Web of Science and Scopus, where associations with the terms were applied in both databases: "Piper" and "Ethnobotanical" and "Piper" and "Anti-inflammatory effect". Initially, the research identified 153 articles, of which 24 articles were selected for final analysis following the inclusion criteria. The results indicate that the medicinal use of species of the Piper genus entails mainly using of leaves, roots, and fruits, and decoct, maceration and powder for the treatment of inflammatory and respiratory diseases such as asthma and bronchitis. Regarding the evaluation of the anti-inflammatory effect of the genus, only seven species presented studies with their scientifically proven anti-inflammatory effect. Biases in the methodology applied in the studies were observed. In this systematic review, it was noticed that both studies addressed have gaps that can cause damage to future research and that pharmacological studies for inflammation with the use of the species themselves are still limited, with a more job for the isolated compounds of these plants.

Key words: Piper, medicinal, ethnobotanic, anti-inflammatory effect.