Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3710

Review

Bioavailability enhancing activities of natural compounds from medicinal plants

Myung Joo Kang1+, Jae Youl Cho2+, Byung Ho Shim1, Duk Ki Kim1 and Jaehwi Lee1*
1College of Pharmacy, Chung-Ang University, 221 Heuksuk-dong, Dongjak-gu, Seoul 156-756, Korea. 2School of Bioscience and Biotechnology, Kangwon National University, 192-1 Hyoja-2-dong, Chuncheon 200-701, Korea.
Email: [email protected]

  •  Accepted: 16 December 2009
  •  Published: 31 December 2009

Abstract

There is an increasing interest and medical need for the improvement of bioavailability of a large number of drugs. Of the promising approaches, the co-administration of therapeutic agents with natural compounds possessing absorption improving activities has gained great interest in oral drug delivery.Many natural compounds from medicinal plants have demonstrated capacity to enhance the bioavailability of co-administered drugs by inhibiting efflux pumps or oxidative metabolism, and perturbing the intestinal brush border membrane. These natural compounds include quercetin, genistein, naringin, sinomenine, piperine, glycyrrhizin and nitrile glycoside. This article reviews the improvement of drug bioavailabilities exhibited specially by natural compounds from plants mentioned above.

 

Key words: Bioavailability enhancer, natural compound, absorption, P-glycoprotein.