The aim of this study was to compare the short-term efficacy and safety of aAzadirachta indica mouthrinse on gingival inflammation and microbial plaque, compared to 0.12% chlorhexidine. A double-masked, randomized, parallel armed study was carried out to assess the efficacy of an oral mouthrinse based on leaves of the neem tree reducing gingivitis. Study subjects were recruited from a slum in Brazil. Fifty-four subjects were enrolled and randomly assigned in two groups (26 neem group, 28 chlorhexidine control). Interventions consisted of a seven day therapy of the A. indica-based mouth rinse and chlorhexidine 0.12%, respectively. Plaque index, gingival index and gingival bleeding index were obtained at baseline, as well as after one and four weeks. Additionally, the count of cariogenic bacteria (Streptococcus mutans) in the saliva was assessed before and after treatment. All clinical index scores were reduced in both groups seven and 30 days after treatment. There was no statistically significant difference between groups in clinical and microbiological parameters. Adverse events were mild and of transient nature. This short-term study demonstrated that A. indica-based mouth rinse is highly efficacious and that it may be used as an alternative therapy in the treatment of periodontal disease.
Keywords: Azadirachta indica, gingivitis, Streptococcus mutans, neem tree, clinical trial.
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