Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3704

Full Length Research Paper

Alternate therapy of Type 2 diabetes mellitus (T2DM) with Nigella (Ranunculaceae)

M. S. H. Akash1, K. Rehman1, F. Rasool2, A. Sethi3, M. A. Abrar4, A. Irshad5, A. Abid6 and G. Murtaza7*
1Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University Hangzhou (PR) China. 2University College of Pharmacy, the University of Punjab, Lahore, Pakistan. 3Department of Pharmacy, GC University, Faisalabad, Pakistan. 4Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. 5Department of Agriculture, Bahauddin Zakariya University, Multan, Pakistan. 6Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan, Pakistan. 7Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
Email: [email protected]

  •  Accepted: 08 November 2011
  •  Published: 16 December 2011


Type 2 diabetes mellitus (T2DM) is being more incurable due to its complex patho-physiology and failure of conventional anti-diabetic agents to restore the normal architecture and morphology of pancreatic islets and some potential side effects and weight gain. Many agents of plant origin have been used as anti-diabetic agents since ancient time. Among them Nigella sativa L. (Ranunculaceae) is being more popular day by day due to its potential and broad spectrum effects on many diseases but unfortunately, no sufficient scientific data is available. A comprehensive literature (in English only) search was conducted using electronic databases: Medline (1966 to 2010) and EMBASE (1980 to 2010). For a simple search, initially the search terms used were “anti-diabetic agent,” and “N. sativa,” for each search term separately, and then an advanced search was made by combining all search fields in abstract, key words, or title. Recently, a lot of work has been done for the evaluation of anti-diabetic (against type-II diabetes) effect of N. sativa, significant results have been achieved. However, further studies are required to investigate the anti-diabetic (against type-II diabetes) of N. sativa at molecular levels.


Key words: Anti-diabetic agent, in vitro analysis, in vivo studies.