Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3590

Full Length Research Paper

Carbon Tetrachloride (CCl4) - induced Hepatotoxicity in Rats: Curative role of Solanum nigrum

Asif Mir1*, Farida Anjum2, Naveeda Riaz1, Hina Iqbal1, Hussain Mustatab Wahedi1, Jabar Zaman Khan Khattak1, Muhammad Asrar Khan3 and S. A. Malik4
1Department of Bioinformatics and Biotechnology, International Islamic University (IIU), Islamabad, Pakistan. 2Higher Education Commission (HEC), Islamabad, Pakistan. 3Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan. 4Department of Biochemistry, Faculty of Biology, Qauid-i-Azam University, Islamabad, Pakistan.
Email: [email protected], [email protected]

  •  Accepted: 31 August 2010
  •  Published: 04 December 2010

Abstract

Solanum nigrum is used in hepatic disorders in folk medicines. The present study was aimed to evaluate the efficacy of S. nigrum on the liver functions in CClinduced injuries. Enzymatic activities that are .AST, ALT and ALP, microscopic appearance of liver was used as parameter and hepatocurative studies were performed. In case of hepatocurative study that is post treatment of rats with aqueous extracts of plant (500mg/ orally, two doses with 24 h interval) prevented (p < 0.001) CCl4 induced rise in activity of serum Transaminases (ALT and AST) and ALP and alcoholic extract did not prevent the rise of same enzymes compared to the sham control group in which liver was damaged by CClno treatment given. Histological examination of the liver of treated animals with aqueous extract of plant showed that fatty acids change was less in comparison to the sham control group. In treated group reduction in body weight was minimal and live enlargement was also less compared to the animals in sham control group. Treatment with aqueous extract of S. nigrum effectively attenuated the alteration within the parameter of present study and accredits the hepatocurative role of S. nigrum.

 

Key words: Solanum nigrum, hepatocurative, AST, ALT, ALP, histopathology, CCl4induced hepatotoxicity, aqueous extract.

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