This study evaluated the effect of flavonoid fraction (FF) of Platycerium angolense on acetaminophen-induced liver damage in rat with a view to considering the possibility of utilizing the extracts of the plant for the management and treatment of liver related ailments. Powdered leaves of P. angolense were extracted with methanol 70% (v/v) to yield methanolic extract of P. angolense (MEPA). The MEPA followed successive partitioning with n-hexane, chloroform and ethylacetate. The ethylacetate fraction was termed flavonoid fraction (FF). FF was phytochemically screened and total phenolic and flavonoid contents estimated. Biochemical effects of FF on liver marker enzymes (L-alanine and L-aspartate aminotransferases, gamma glutamyltransferase, acid and alkaline phosphatases); lipid profiles (cholesterol, triglycerides, high density lipoprotein (
Key words: Hepatotoxicity, Platycerium angolense, acetaminophen, flavonoids, flavonoid fraction.
Copyright © 2020 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0