Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

The effects of cornelian cherry on atherosclerosis and atherogenic factors in hypercholesterolemic rabbits

Mahmoud Rafieian-Kopaei1, Sedigheh Asgary2, Azadeh Adelnia3, Mahbubeh Setorki4*, Majid Khazaei5, Somayeh Kazemi6 and Fatemeh Shamsi3
1Department of Pharmacology, Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran. 2Pharmacognosy, Isfahan Cardiovascular Research Center and Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 3Department of Biology, University of Payam-Noor,Isfahan, Iran. 4Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran. 5Department of Physiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan. 6Department of Biology, University of Isfahan, Isfahan, Iran.
Email: [email protected]

  •  Accepted: 15 April 2011
  •  Published: 04 July 2011


Atherosclerosis results from gradual deposition of lipids in medium and large arteries and is the leading cause of death world wide. Due to the side effects of chemical compounds more attention has been paid to herbal remedies. This study was aimed to evaluate the curative effects of Cornus mas on atherosclerosis and its risk factors in hypercholesterolemic rabbits. Twenty-five male New-Zealand rabbits weighing 2 to 2.5 kg were randomly desigrated into five groups of five and were fed for 60 days using the following diet regimens: Standard diet, standard diet plus C. mas (1 g/kg bw, daily), hypercholesterol diet (1%), hypercholesterol diet plus C. mas (1 g/kg bw, daily), hypercholesterol diet plus lovastatin (10 mg/kg bw, Daily). The concentration of total cholesterol (TC), LDL cholesterol, triglycerides (TG) HDL cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), antioxidant capacity, malondialdehyde (MDA) and fibrinogen were determined in rabbits in the beginning and at the end of the experiment. Fatty streak formation was also evaluated. C. mas powder significantly increased antioxidant capacity and decreased MDA, fibrinogen and AIP (AIP = log TG/HDL) in plasma. It also decreased TC, LDL and TG levels and atherosclerotic lesion in the aorta, although the reduction was not statisticant. Results showed that consumption of C. mas might be beneficial in hypercholesterolemic patients due to its antioxidant and anti-inflammatory properties. 

Key word: Atherosclerosis, Cornus mas, hypercholesterolemia, rabbit.