Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3761

Full Length Research Paper

Protective effect of commercial extracts of oregano (Lippia graveolens) against cardiac ischemia-reperfusion damage

Gabriela Pérez Flores
  • Gabriela Pérez Flores
  • Facultad de Estudios Zona Huasteca – Universidad Autónoma de San Luis Potosí, México.
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Jose David Torres Tirado
  • Jose David Torres Tirado
  • Facultad de Estudios Zona Huasteca – Universidad Autónoma de San Luis Potosí, México.
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Ramiro Martínez Acosta
  • Ramiro Martínez Acosta
  • Integradora de Productos y Servicios Oreganic SPR de RI, México.
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Jorge Alejandro Chavez Aguirre
  • Jorge Alejandro Chavez Aguirre
  • Facultad de Ciencias Químicas-Universidad Juárez del Estado de Durango, México.
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María Guadalupe Nieto Pescador
  • María Guadalupe Nieto Pescador
  • Facultad de Ciencias Químicas-Universidad Juárez del Estado de Durango, México.
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Maribel Cervantes Flores
  • Maribel Cervantes Flores
  • Facultad de Ciencias Químicas-Universidad Juárez del Estado de Durango, México.
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Ashley Stephanie Herrera Godina
  • Ashley Stephanie Herrera Godina
  • Facultad de Ciencias Químicas-Universidad Juárez del Estado de Durango, México.
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Eduardo Lozano Guzman
  • Eduardo Lozano Guzman
  • Facultad de Ciencias Químicas-Universidad Juárez del Estado de Durango, México.
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  •  Received: 03 March 2021
  •  Accepted: 14 September 2021
  •  Published: 31 October 2021

Abstract

Cardiac ischemia includes severe damage to heart muscle tissue due to decreased or cessation of blood flow, which involves failure to supply nutrients and oxygenation to heart cells. Causes can include blockages due to fat and cholesterol deposits. These damages include cell apoptosis, calcium and sodium concentration imbalance, loss of contraction force, and formation of reactive oxygen species. In the present work, oregano extracts administered to Wistar rats were tested. After 15 days of treatment, the hearts were extracted and the pharmacological response was evaluated in Langendorff isolated perfused heart assay. Left ventricular contractility and perfusion pressure were evaluated before and after inducing an ischemia-reperfusion event by administering three different drugs to stimulate said response. The results, expressed as a percentage of loss of cardiac functionality, suggest a protective effect against cardiac damage in those hearts treated with the extracts after each event.

Key words: Wistar rats, cardiac ischemia, Langendorff, oregano extracts.