Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3714

Full Length Research Paper

Comparison of allopathic and herbal medicine for the treatment of Entamoeba histolytica: A double blind clinical trial

Muhammad Irfanullah Siddiqui*
  • Muhammad Irfanullah Siddiqui*
  • Hamdard College of Medicine, Hamdard University, Karachi, Pakistan. 2Hamdard College of Eastern Medicine, Hamdard University, Karachi, Pakistan.
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Khan Usmanghani
  • Khan Usmanghani
  • Hamdard College of Eastern Medicine, Hamdard University, Karachi, Pakistan.
  • Google Scholar

  •  Received: 12 June 2014
  •  Accepted: 19 February 2015
  •  Published: 03 March 2015


This parallel, randomized, double blind clinical trial was designed to compare allopathic drugs [a combination of metronidazole + diloxanide furoate (MDF)] with Endemali (herbal product) for therapeutic cure rate and side effects in order to find out the most suitable drug for this killer disease. This double blind randomized clinical trial was conducted in two areas of Karachi, Pakistan after approval from ethical committee of Hamdard University. All those confirmed for Entamoeba histolytica were included in the study. One hundred and seventy one patients selected for the study were randomly allocated to two arms of 86 and 85 for allopathic and herbal treatment, respectively. However 78 in allopathic and 75 in herbal group completed the study. Main outcome variable was treatment success or failure. Secondary outcome measures included side effects and association with age and sex. No significant difference was observed in the socio economic and demographic variables at the baseline. No significant difference was found between the cure rate of MDF and Endemali; hence both drugs were equally effective in treating amoebiasis. Significant differences were reported for the side effects observed among the two groups and the price. The failure rate for the two drugs was 28.7%. It is concluded that both Endemali and MDF are equally effective in treating amoebiasis. However, Endemali has fewer side effects than MDF. New drugs need to be researched for the treatment of E. histolytica because of high failure rate of the two drugs against this killer organism.


Key words: Comparison, Entamoeba histolytica, amoebiasis, herbal, Endemali, metronidazole, diloxanide furoate, clinical trial, double blind, parallel.