Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3830

Short Communication

Inhibition effects on HBV replication by hydrophobic extracts from Ferula ferulaeoides (Steud.) Korov

L. L. Zhai1, T. Liu2, H. Q. Xie3, Y. H. Xie1 and Q. Mu2*
1School of Pharmacy, Fudan University, Shanghai 200032, China. 2Key Laboratory of Medical Molecular Virology, MOE/MOH, Shanghai Medical College, Fudan University, Shanghai 200032, China. 3Department of Plant Protection, Agricultural School, Shihezi University, Xinjiang 832002, China.
Email: [email protected]

  •  Published: 09 December 2011

Abstract

Hepatitis B virus (HBV) infection is a worldwide public health problem, which can lead to life threatening chronic hepatitis, liver cirrhosis and cancer. Despite this, treatments for chronic HBV infection are still very limited. In our investigation herbal medicines as antiviral agents, FF, the lipid soluble fraction of Ferula ferulaeoides, which has been used as a traditional Chinese medicine, showed a significant inhibitory effect against HBV in HBV-producing cell line HepG2.2.15. In the experiment, FF reduced the HBsAg level and HBV replication by 87% and 36%, respectively. The results suggest the lipophilic fraction of root extracts from F. ferulaeoides could serve as a effective natural constituents of herbs for the search of novel anti-HBV agents.

 

Key words: Hepatitis B Virus, anti-HBV, HBsAg, Ferula ferulaeoides.

Abbreviation

FF, The lipid soluble fraction of Ferula ferulaeoides; HBV, hepatitis B virus;ORF, open reading frames; DMSO, dimethyl sulfoxide; SD, standard deviation; RT-PCR,real-time polymerase chain reaction.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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