Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3846

Full Length Research Paper

Antiplasmodial activity of compounds isolated from Elaeagnus umbellata

Fiaz Aziz Minhas, Shahid Aziz*, Habib-ur-Rehman, Muhammad Irshad, Muhammad Naeem Ahmed and Khawaja Ansar Yasin      
Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad-13100, Pakistan.    
Email: [email protected]

  •  Accepted: 27 December 2011
  •  Published: 10 February 2013

Abstract

The study of the chemical constituents of the whole plant of Elaeagnus umbellata has resulted in the isolation and characterization of three coumarins, namely, 7-Hydroxy-chromen-2-one (1), 7, 8-Dihyroxy-chromen-2-one (2), 3-(2,2,3,4,5-Pentahydroxy-hexyloxy)-chromen-2-one (3) and an anthraquinone (4) together with β-sitosterol glucopyranoside (5) and lupeol (6). The structural elucidation of the isolated compounds was established based on spectroscopic studies. The in vitro antimalarial activity of compounds 1 to 4 againstPlasmodium falciparum shows partial suppression of parasitic growth.

 

Key words: Elaeagnus umbellata, coumarins, anti-malarial activity.      

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This article is published under the terms of the Creative Commons Attribution License 4.0

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