Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3843

Full Length Research Paper

Preliminary phytochemical and biological screening of methanolic and acetone extracts from Leonotis nepetifolia (L.) R. Br.

Danuta Sobolewska1*, PaweÅ‚ PaÅ›ko2, Agnieszka Galanty1, Justyna Makowska-WÄ…s1, Kinga PadÅ‚o1 and Wojciech Wasilak1
1Department of Pharmacognosy, Jagiellonian University, Medical College, Krakow, Poland. 2Department of Food Chemistry and Nutrition, Jagiellonian University, Medical College, Krakow, Poland.
Email: [email protected]

  •  Accepted: 28 May 2012
  •  Published: 31 August 2012

Abstract

This study is aimed at preliminary phytochemical analysis and determination of biological activity of methanolic extract (ME) and acetone extract (AE) from aerial parts of Leonotis nepetifolia (L.) R. Br. collected from Southern Brazil. Phytochemical analysis demonstrated the presence of terpene compounds, flavonoids, tannins, iridoids, sterols and fats. The extracts were inactive towards selected strains of Gram (+), Gram (-) bacteria and dermatophytes at concentrations up to 50 mg/ml, demonstrated antioxidative ability measured by ferric reducing ability of plasma (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods and exhibited cytotoxic in vitro activity towards Du145 human prostate cancer cell line.

 

Key words: Leonotis nepetifolia, antioxidant capacity, Du145 cells.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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