Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3785

Full Length Research Paper

Antibacterial effects of S-(-)-tulipalin B isolated from Spiraea thunbergii Sieb. on Escherichia coli, a major food borne pathogenic microorganism

Jiyoung Lee1, Jongsung Lee1, Jihee Lim1, Sanghee Sim2 and Deokhoon Park1*    
1Biospectrum Life Science Institute, SK Ventium 101-701, #522 Dangjung Dong, Gunpo City, Gyunggi Do, Rep. of Korea.   2School of Biotechnology, Yeungnam University, Gyeongsan City, Gyeongsangbuk Do, Republic of Korea.    
Email: [email protected]

  •  Accepted: 08 February 2008
  •  Published: 31 March 2008


The crude ethanol extract of the leaves of Spiraea thunbergii Sieb. (Rosaceae) showed antibacterial activity against a food borne pathogen, Escherichia coli. Bioactivity-guided separation led to the isolation of a butyrolaton, 1(S-(-)-tulipalin B). The structure was determined from the interpretation of spectroscopic data (UV, MS, and NMR). The minimal inhibitory concentration (MIC) of compound 1 against E. coli was found to be 100/ml. In addition, we found the possibility that a methylene group may operate as a key factor in the antibacterial activities of compound 1 and the hydroxyl group may exert a synergistic effect with the methylene group.


Key words: Spiraea thunbergii Sieb., antibacterial activity, butyrolactones, S-(-)-tulipalin B, Escherichia coli.