Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3804

Full Length Research Paper

In vitro and in vivo inhibitory action of a novel antibiotic on mouse hepatoma H22

Basic Medicine College, Zhejiang Chinese Medicine University, Binwen Road 548,Binjiang District, Hangzhou City, Zhejiang Province, P. R. China.
Email: [email protected]

  •  Accepted: 28 January 2011
  •  Published: 18 April 2011


IC50 for a novel antibiotic against mouse hepatoma H22 was determined to be 0.019 μg/mL by MTT assays. In KM mice bearing this kind of tumor that was treated by s.c. injection of antibiotic BS, marked cures were obtained. In terms of tumor weight, the treated/control=0.35. The conclusion is that BS merit further investigation as a potential anti-cancer candidate drug.


Key words: Bacillus subtilis, antibiotic, in vivo, in vitro, antitumor.