Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3839

Full Length Research Paper

Dipeptide and xanthones from Artocarpus kemando Miq.

Najihah Mohd. Hashim1, Mawardi Rahmani1*, Shireen Shaharina Shamaun1, Gwendoline Cheng Lian Ee1, Mohd Aspollah Sukari1, A. Manaf Ali2 and Rusea Go3
1Department of Chemistry, Universiti Putra Malaysia 43400 UPM, Serdang, Selangor, Malaysia. 2Department of Cell and Molecular Biology, Universiti Putra Malaysia 43400 UPM, Serdang, Selangor, Malaysia. 3Department of Biology, Universiti Putra Malaysia 43400 UPM, Serdang, Selangor, Malaysia.
Email: [email protected]

  •  Accepted: 03 May 2011
  •  Published: 09 September 2011

Abstract

The ground air-dried stem bark of Artocarpus kemando Miq. (Moraceae) collected from Sarawak, Malaysia was subjected to sequential extraction with hexane, chloroform and methanol to give three crude extracts. Silica gel chromatographic separation of the chloroform extract yielded a dipeptide, aurantiamide benzoate, cycloartobiloxanthone, dihydroartoindonesianin C and 6,7-dimethoxycoumarin. All compounds were obtained as crystals and their structures were determined on the basis of spectroscopic data, including UV, IR, MS, 1D- and 2D-NMR and comparison with known related compounds. This is the first report on the identification of a peptide in Artocarpus species.

 

Key words: Artocarpus kemando, aurantiamide benzoate, dihydroartoindonesianin C, cycloartobiloxanthone, 6,7-dimethoxycoumarin.