Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Salvia sahendica prevents tissue damages induced by alcohol in oxidative stress conditions: Effect on liver and kidney oxidative parameters

Mohammad Ali Esmaeili1*, Ali Sonboli1, Mohammad Reza Kanani1 and Heibatollah Sadeghi2
1Department of Biology, Medicinal Plants and Drug Research Institute, Shahid Beheshti University, G. C.  Evin, Tehran, Iran. 2Department of Biochemistry, School of Medicine, Yasouj University of MedicalSciences, Yasouj, Iran.
Email: [email protected]

  •  Accepted: 31 March 2009
  •  Published: 30 April 2009

Abstract

Oxidative stress plays an essential role in the development of alcohol liver disease. The present study represents the protective effect of a polyphenolic rich extract of Salvia sahandica against liver and kidney damages in alcohol-induced oxidative stress. Measurement antioxidant activity by scavenging of 1,1-diphenyl-2-picrylhydrazyl radical showed that methanolic extract of S. sahendica possesses the highest antioxidant activity. Treatment of experimental rats with ethanol for one month showed an increase in activities of liver marker enzymes, lipid peroxidation marker (TBARS) with significantly lower activity of enzymatic and non-enzymatic antioxidants in rat liver and kidney compared to those in normal rats. Treatment alcohol rats with S. sahendica at a dose of (0.1 g/kg) significantly reduced the level of lipid peroxidation and liver marker enzymes and restored the enzymic and non-enzymatic antioxidants levels in liver and kidney of treated rats. The results of this study strongly indicate that S. sahendica has potent hepato-protective effect against alcohol induced tissues damage in experimental animals. This study also suggests that possible mechanism of this activity may be due to the presence of flavonoids and phenolics compound(s) in the methanolic extract of S. sahendicawhich may be responsible to hepato-protective activity.

 

Key words: Salvia sahendica, alcohol, antioxidant, lipid peroxidation, oxidative stress.