Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3693

Full Length Research Paper

The antiulcer and antioxidant mechanisms of the butanolic fraction extract obtained from Bauhinia forficata leaves: A medicinal plant frequently used in Brazilian folk medicine

Barbara Gomes Del Rey
  • Barbara Gomes Del Rey
  • Natural Products Laboratory Research, Universidade Santa Cecília, CEP 11045-907, Santos-SP, Brazil.
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Luciana Lopes Guimaraes
  • Luciana Lopes Guimaraes
  • Natural Products Laboratory Research, Universidade Santa Cecília, CEP 11045-907, Santos-SP, Brazil.
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Marcos Sergio de Toledo
  • Marcos Sergio de Toledo
  • Laboratory of Glycoconjugate Immunochemistry, Department of Biochemistry, Escola Paulista de Medicina, Universidade Federal de São Paulo, CEP 04023-900, São Paulo-SP, Brazil.
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Helio Kiyoshi Takahashi
  • Helio Kiyoshi Takahashi
  • Laboratory of Glycoconjugate Immunochemistry, Department of Biochemistry, Escola Paulista de Medicina, Universidade Federal de São Paulo, CEP 04023-900, São Paulo-SP, Brazil.
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Anita Hilda Straus
  • Anita Hilda Straus
  • Laboratory of Glycoconjugate Immunochemistry, Department of Biochemistry, Escola Paulista de Medicina, Universidade Federal de São Paulo, CEP 04023-900, São Paulo-SP, Brazil.
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Monike Silva de Freitas
  • Monike Silva de Freitas
  • Natural Products Laboratory Research, Universidade Santa Cecília, CEP 11045-907, Santos-SP, Brazil.
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Bruna Hattebberger
  • Bruna Hattebberger
  • Pharmacy Course, Centro Universitário São Camilo, Campus Ipiranga, CEP 04263-200, São Paulo-SP, Brazil.
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Cláudia Maria Moraes Silva
  • Cláudia Maria Moraes Silva
  • Pharmacy Course, Centro Universitário São Camilo, Campus Ipiranga, CEP 04263-200, São Paulo-SP, Brazil.
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Matheus Roberti de Carvalho
  • Matheus Roberti de Carvalho
  • Pharmacy Course, Centro Universitário São Camilo, Campus Ipiranga, CEP 04263-200, São Paulo-SP, Brazil.
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Walber Toma
  • Walber Toma
  • Natural Products Laboratory Research, Universidade Santa Cecília, CEP 11045-907, Santos-SP, Brazil.
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  •  Received: 30 December 2017
  •  Accepted: 06 February 2018
  •  Published: 10 February 2018

Abstract

The objectives of this work were to evaluate the antiulcer activity, antioxidant mechanisms, phytochemical analysis and ecotoxicological risk of the butanolic fraction (ButFr) obtained from the leaf extracts of Bauhinia forficata. In an ischemia-reperfusion (IR), gastric ulcer model with doses 12.5 and 6.25 mg kg-1 promoted significant decreases in the ulcerative lesion area (ULA) by 50% (p<0.001) and 46% (p<0.001), respectively. Regarding the antioxidant mechanisms, the dose of 6.25 mg kg-1 promoted a significant increase in SOD (41%), GPx (62.7%) and GR (54.5%) activities (p <0.001) when compared to the negative control. 38% reduction in Myeloperoxidase activity (MPO) activity was also observed as well as 35.5% reduction in the LPO index when compared to the negative control (p <0.001). Phytochemical analysis demonstrated the presence of flavonoids (kaempferitrin and rutin) in ButFr, compounds responsible for the pharmacological activities observed. Conclusively the ButFr has antiulcer activity via antioxidant mechanisms. 
 
Key words: B. forficata, Pata-de-Vaca, antiulcerogenic, phytochemistry.